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There are several matches for '3'-RNA processing protein'.
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1058 matches
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organism
protein
1)
Homo sapiens
PNPT1 - Polyribonucleotide nucleotidyltransferase 1, mitochondrial;
RNA
-binding
protein
implicated in numerous
RNA
metabolic
processes
. Catalyzes the phosphorolysis of single-stranded polyribonucleotides
processively
in the
3
'-to-5' direction. Mitochondrial intermembrane factor with
RNA
-
processing
exoribonulease activity. Component of the mitochondrial degradosome (mtEXO) complex, that degrades
3
' overhang double-stranded
RNA
with a
3
'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules. Require [...]
[a.k.a. AAK13047.1, 5ZF6, DFNB70]
2)
Homo sapiens
ELAVL4 - ELAV-like
protein
4;
RNA
-binding
protein
that is involved in the post- transcriptional regulation of mRNAs. Plays a role in the regulation of mRNA stability, alternative splicing and translation. Binds to AU-rich element (ARE) sequences in the
3
' untranslated region (UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA. Many of the target mRNAs are coding for
RNA
-binding
proteins
, transcription factors and
proteins
involved in
RNA
processing
and/or neuronal development and function (By similarity). By binding to the mRNA
3
'UTR, decreases mRNA deadenylation and thereby [...]
[a.k.a. XM_024453827.1, CCDS553, ENSP00000399939]
3)
Homo sapiens
MPHOSPH6 - M-phase phosphoprotein 6;
RNA
-binding
protein
that associates with the
RNA
exosome complex. Involved in the
3
'-
processing
of the 7S pre-
RNA
to the mature 5.8S rRNA and play a role in recruiting the
RNA
exosome complex to pre- rRNA; this function may include C1D.
[a.k.a. CCDS10937, AAH11020.1, ENSG00000135698]
4)
Homo sapiens
SLBP - Histone
RNA
hairpin-binding
protein
;
RNA
-binding
protein
involved in the histone pre-mRNA
processing
. Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient
3
'-end
processing
by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery. Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expressio [...]
[a.k.a. Z71188, NX_Q14493, SLBP-204]
5)
Homo sapiens
TARDBP - TAR DNA-binding
protein
43;
RNA
-binding
protein
that is involved in various steps of
RNA
biogenesis and
processing
. Preferentially binds, via its two
RNA
recognition motifs RRM1 and RRM2, to GU-repeats on
RNA
molecules predominantly localized within long introns and in the
3
'UTR of mRNAs. In turn, regulates the splicing of many non-coding and
protein
-coding RNAs including
proteins
involved in neuronal survival, as well as mRNAs that encode
proteins
relevant for neurodegenerative diseases. Plays a role in maintaining mitochondrial homeostasis by regulating the
processing
of mitochondria [...]
[a.k.a. ENSP00000467020, XM_017000868, ENST00000240185]
6)
Homo sapiens
XRN2 - 5'-3' exoribonuclease 2; Possesses 5'->
3
' exoribonuclease activity (By similarity). May promote the termination of transcription by
RNA
polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently
processed
to form the mature mRNA and a
3
' fragment which remains attached to the elongating polymerase. The
processive
degradation of this
3
' fragment by this
protein
may promote termination of transcription. Binds to
RNA
polymerase II (RNAp II) transcription termination R-loops formed by G- rich pause sites. Belongs to t [...]
[a.k.a. Q9UL53, ENST00000377191.4, 5'-3' exoribonuclease 2]
7)
Homo sapiens
EDC3 - Enhancer of mRNA-decapping
protein
3
; Binds single-stranded
RNA
. Involved in the
process
of mRNA degradation and in the positive regulation of mRNA decapping. May play a role in spermiogenesis and oogenesis.
[a.k.a. ENST00000315127, EDC3-215, BAB15001.1]
8)
Homo sapiens
LSM6 - U6 snRNA-associated Sm-like
protein
LSm6; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the
3
'-terminal U-tract of U6 snRNA. Component of LSm
protein
complexes, which are involved in
RNA
processing
and may function in a chaperone-like manner, facilitating the efficient association of
RNA
processing
factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is tho [...]
[a.k.a. 6AH0, R-HSA-72203, XM_017007673.1]
9)
Homo sapiens
NONO - Non-POU domain-containing octamer-binding
protein
; DNA- and
RNA
binding
protein
, involved in several nuclear
processes
. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and
RNA
at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the
3
' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclea [...]
[a.k.a. ENST00000454976.1, ENST00000471419, NonO protein]
10)
Homo sapiens
CPEB4 - Cytoplasmic polyadenylation element-binding
protein
4; Sequence-specific
RNA
-binding
protein
that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA
3
'-UTR.
RNA
binding results in a clear conformational change analogous to the Venus fly trap mechanism. Regulates activation of unfolded
protein
response (UPR) in the
process
of adaptation to ER stress in liver, by maintaining translation of CPE- regulated mRNAs in conditions in which global
protein
synthesis is inhibited (By similarity). Required for [...]
[a.k.a. ENSP00000334533, CCDS4390.1, ENST00000334035.9]
11)
Homo sapiens
ILF3 - Interleukin enhancer-binding factor
3
;
RNA
-binding
protein
that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back- splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs
processing
by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs. As a consequence, participates in a wide range of transcriptional and post- transcriptional
processes
. Binds to poly-U elements and AU-rich elements (AREs) in the
3
'-UTR of tar [...]
[a.k.a. XM_017026763.1, NFAR-1, K7EPG3]
12)
Homo sapiens
RCL1 -
RNA
3
'-terminal phosphate cyclase-like
protein
; Does not have cyclase activity. Plays a role in 40S- ribosomal-subunit biogenesis in the early pre-rRNA
processing
steps at sites A0, A1 and A2 that are required for proper maturation of the 18S
RNA
(By similarity).
[a.k.a. UPI0000458894, ENST00000381732.3, RTC2]
13)
Homo sapiens
NCL - Nucleolin; Nucleolin is the major nucleolar
protein
of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the
process
of transcriptional elongation. Binds
RNA
oligonucleotides with 5'-UUAGGG-
3
' repeats more tightly than the telomeric single-stranded DNA 5'- TTAGGG-3' repeats.
[a.k.a. CCDS33397, ENST00000417652, ENST00000322723]
14)
Homo sapiens
C1D - Nuclear nucleic acid-binding
protein
C1D; Plays a role in the recruitment of the
RNA
exosome complex to pre-rRNA to mediate the
3
'-5' end
processing
of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB (By similarity).
[a.k.a. ENST00000407324.5, NX_Q13901, OTTHUMG00000129564]
15)
Homo sapiens
YTHDF3 - YTH domain-containing family
protein
3
; Specifically recognizes and binds N6-methyladenosine (m6A)- containing RNAs and promotes
RNA
translation efficiency. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing,
processing
and stability. Shares m6A-containing mRNAs targets with YTHDF1 and YTHDF2, and regulates different
processes
depending on the context. Facilitates the translation of targeted mRNAs in cooperation with YTHDF1 by binding to m6A-containing mRNAs and interacting with 40S and 60S ribosome subu [...]
[a.k.a. ENSP00000478825, NR_102434.1, ENST00000613853.4]
16)
Homo sapiens
ZC3H13 - Zinc finger CCCH domain-containing
protein
13; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and
RNA
processing
. Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the
3
'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RN [...]
[a.k.a. Xio, ENST00000378920, XP_016875966]
17)
Homo sapiens
VIRMA -
Protein
virilizer homolog; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and
RNA
processing
. Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the
3
'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites. Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the
3
'-UTR near the stop codon corr [...]
[a.k.a. NM_015496, AB037850, HGNC:24500]
18)
Homo sapiens
RBM5 -
RNA
-binding
protein
5; Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and
3
' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this
process
, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby pr [...]
[a.k.a. UPI000198CA8E, F8W910, B4DMF9]
19)
Homo sapiens
PABPN1 - Polyadenylate-binding
protein
2; Involved in the
3
'-end formation of mRNA precursors (pre- mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring
processivity
on the poly(A) tail elongation reaction and controls also the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for
RNA
(By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to syner [...]
[a.k.a. D3DS49, R-HSA-168254, NM_004643.3]
20)
Homo sapiens
TAF3 - Transcription initiation factor TFIID subunit
3
; Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by
RNA
polymerase II. TFIID is a multimeric
protein
complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation
process
.
[a.k.a. R-HSA-162587, AJ292190, R-HSA-73776]
1058 matches
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